Figure 3.

Crosstalk of NETosis with other forms of cell death and implications for gout. Monosodium urate (MSU) -stimulated NETs require key molecules involved in necroptosis. Neutrophils can promote cytokine degradation by forming NETs, phagocytosing MSU, and physically isolating them to suppress inflammation. Histones released during NETosis may have cytotoxic and immunostimulatory effects on cells. In addition, crosstalk with other forms of cell death, including pyroptosis and autophagy, may occur.