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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: Microcirculation. 2020 Dec 30;28(4):e12674. doi: 10.1111/micc.12674

FIGURE 8.

FIGURE 8

Endothelium-dependent ACh-induced vasorelaxations of small mesenteric arteries. Endothelium-dependent ACh-mediated relaxations in the presence of the cyclooxygenase blocker indomethacin (10 μM) (A and B), NO-dependent ACh-mediated relaxations in the presence of indomethacin, TRAM-34 (1 μM) and UCL 1684 (1 μM) (C and D), and endothelium-dependent hyperpolarizing (EDH) relaxing responses in the presence of indomethacin and the non-selective NOS blocker L-NAME (E and F) for small mesenteric arteries isolated from NT (A, C and E) and dnTrx-Tg (B, D and F) mice fed a normal chow (NC) diet (circles), high fat/high sucrose (HFS) diet (squares), and HFS followed by tail vein injection of the ONOO− decomposition compound FeTMPyP (triangles). Values are shown as means ± SEM. *p < .05 versus NC. Number of mice (n = 7, males and females)