FIGURE 9.
Endothelium-independent relaxing responses in small mesenteric arteries. Endothelium-independent sodium nitroprusside (SNP; 0.1 nM-1 μM)-mediated relaxations in the presence of L-NAME and indomethacin for small mesenteric arteries isolated from NT (A) and dnTrx-Tg (B) mice fed a normal chow (NC) diet (circles), high fat/high sucrose (HFS) diet (squares), and HFS followed by tail vein injection of the ONOO− decomposition compound FeTMPyP (triangles). Values are shown as means ± SEM. *p < .05 versus NC. Number of mice (n = 5, males and females)