α-Glucosidase inhibitory activity of divalent metal complexes bearing hydrazide ligands.

Entry	Compounds	Structure number	IC50 (μM)	Ref.
1		L1	NA	53 a
		L2	NA
		L3	47.51
		L4	NA
		L5	NA
		L6	396.35
		L7	NA
		L8	240	54 b
		L9	230
		L10	Not reported clearly	55 b
2				53 a
2a
	1 = [Zn(L1)2]Cl2	1 X = N; Y = C; R1 = H; R2 = H	101.29
	2 = [Zn(L2)2]Cl2	2 X = C; Y = N; R1 = H; R2 = H	56.27
	3 = [Zn(L3)2]Cl2	3 X = C–NO2; Y = C; R1 = H; R2 = H	27.71
	4 = [Zn(L4)2]Cl2	4 X = C; Y = C; R1 = H; R2 = NO2	97.26
	5 = [Zn(L5)2]Cl2	5 X = C; Y = C–NH2; R1 = H; R2 = H	NA
	6 = [Zn(L6)2]Cl2	6 X = C; Y = C; R1 = Br; R2 = H	121.19
2b
	9 = [Cu(L1)2]Cl2	9 X = N; Y = C; R1 = H; R2 = H	>500
	10 = [Cu(L2)2]Cl2	10 X = C; Y = N; R1 = H; R2 = H	17.73
	11 = [Cu(L3)2]Cl2	11 X = C–NO2; Y = C; R1 = H; R2 = H	1.15
	12 = [Cu(L4)2]Cl2	12 X = C; Y = C; R1 = H; R2 = NO2	18.91
	13 = [Cu(L5)2]Cl2	13 X = C; Y = C–NH2; R1 = H; R2 = H	0.15
	14 = [Cu(L6)2]Cl2	14 X = C; Y = C; R1 = Br; R2 = H	0.21
	15 = [Cu(L7)2]Cl2	15 X = C; Y = C; R1 = H; R2 = Cl	NA
2c
	22 = [Co(L1)2]Cl2	22 X = N; Y = C; R1 = H; R2 = H	NA
	23 = [Co(L2)2]Cl2	23 X = C; Y = N; R1 = H; R2 = H	66.48
	24 = [Co(L3)2]Cl2	24 X = C–NO2; Y = C; R1 = H; R2 = H	153.23
	25 = [Co(L4)2]Cl2	25 X = C; Y = C; R1 = H; R2 = NO2	96.95
	26 = [Co(L5)2]Cl2	26 X = C; Y = C–NH2; R1 = H; R2 = H	NA
	27 = [Co(L6)2]Cl2	27 X = C; Y = C; R1 = Br; R2 = H	213.30
	28 = [Co(L7)2]Cl2	28 X = C; Y = C; R1 = H; R2 = Cl	NA
2d
	30 = [Mn(L1)2]Cl2	30 X = N; Y = C; R1 = H; R2 = H	45.63
	31 = [Mn(L2)2]Cl2	31 X = C; Y = N; R1 = H; R2 = H	143.21
	32 = [Mn(L3)2]Cl2	32 X = C–NO2; Y = C; R1 = H; R2 = H	345.62
	33 = [Mn(L4)2]Cl2	33 X = C; Y = C; R1 = H; R2 = NO2	NA
	34 = [Mn(L5)2]Cl2	34 X = C; Y = C–NH2; R1 = H; R2 = H	NA
	35 = [Mn(L7)2]Cl2	35 X = C; Y = C; R1 = H; R2 = Cl	457.28
3				54 b
3a
	7 = [Zn(L8)2]·2H2O	7	180
3b
	M(ii) = Cu, Ni
	16 = [Cu(L8)2(OH2)2]·H2O	16	140
	19 = [Ni(L8)2(OH2)2]·H2O	19	200
3c
	8 = [Zn(L9)CH3COO]·H2O	8	190
3d
	M(ii) = Cu, Ni
	17 = [Cu(L9)2(OH2)2]·H2O	17	170
	20 = [Ni(L9)2(OH2)2]·H2O	20	230
4				55 b
	M(ii) = Cu, Ni, Co, Mn
	18 = [Cu(L10)2]	18	Not reported clearly
	21 = [Ni(L10)2]	21	Not reported clearly
	29 = [Co(L10)2]	29	Not reported clearly
	36 = [Mn(L10)2]	36	Not reported clearly

^aAcarbose as the reference drug (IC₅₀ = 378.25 μM).

^bAcarbose as the reference drug (IC₅₀ = 99 μM).