α-Glucosidase inhibitory activity of divalent metal complexes bearing picolinic acid (PicAs).

Entry	Compounds	Structure number	IC50 (μM)	Ref.
1		L11	NA	62 a
		L12	NA	62 a
		L13	NA	63 a
		L14	NA	63 a
		L15	NA	67 a
		L16	Not reported	64 a
		L17	NA	68 a
		L18	NA	68 a
		L19	NA	65 a
		L20	NA	65 a
2				64 a
2a
	M(ii) = Zn, Cu
	37 = [Zn(L11)2(H2O)]	37	546.04
	42 = [Cu(L11)2(H2O)]	42	2.95
2b
	43 = [Cu(L11)2(L16)]	43	3.49
2c
	M(ii) = Ni, Co, Mn
	48 = [Ni(L11)2(H2O)2]	48	>600
	53 = [Co(L11)2(H2O)2]	53	>600
	61 = [Mn(L11)2(H2O)2]	61	>600
3
	44 = [Cu(L11)2(NCS)]	44	8.02	66 b
4				67 a
4a
	45 = [Cu(L11)(L15)(NO3)]	45	688.94
4b
	M(ii) = Ni, Mn
	49 = [Ni(L11)(L15)(H2O)2]	49	>600
	62 = [Mn(L11)(L15)(H2O)2]	62	>600
4c
	59 = [Fe(L11)(L15)(H2O)2]	59	97.33
	60 = [Fe(L17)(L15)(H2O)2]	60	724.25
4d
	54 = [Co(L11)2(L15)]	54	>600
5
	M(ii) = Zn, Ni
	38 = [Zn(L11)(L12)(Cl)2]	38	>600	62 a
	50 = [Ni(L11)(L12)(Cl)2]	50	>600
6				63 a
6a
	39 = [Zn(L11)2(L13)]	39	>600
6b
	46 = [Cu(L11)(L13)(CH3COO)]	46	513.10
6c
	55 = [Co(L11)(L13)(Cl)2]	55	>600
7				63 a
7a
	M(ii) = Zn, Co, Mn
	40 = [Zn(L11)2(L14)2]	40	>600
	56 = [Co(L11)2(L14)2]	56	>600
	63 = [Mn(L11)2(L14)2]	63	>600
7b
	47 = [Cu(L11)2(L14)]	47	2.91
7c
	51 = [Ni(L11)2(L14)(CH3COO)]	51	>600
8				68 a
8a
	M(ii) = Ni, Co, Mn
	52 = [Ni(L11)2(L18)]	52	>600
	57 = [Co(L11)2(L18)]	57	>600
	64 = [Mn(L11)2(L18)]	64	>600
8b
	58 = [Co(L17)2(L18)]	58	>600
9
	41 = [Zn(L19)(L20)(H2O)2]	41	440	65 a

^aGenistein as the reference drug (IC₅₀ = 16.57 ± 0.23 μM).

^bGenistein as the reference drug (IC₅₀ = 7.85 ± 0.87 μM).