α-Glucosidase inhibitory activity of divalent metal complexes bearing Schiff base ligands.
Entry | Compounds | Structure number | Yeast enzyme | rat intestinal enzyme | Ref. |
---|---|---|---|---|---|
IC50 (μM) | IC50 (μM) | ||||
1 | L21 | NA | NA | 72 a | |
L22 | NA | NA | |||
L23 | NA | NA | |||
L24 | NA | NA | |||
2 | 72 a | ||||
2a | |||||
65 = [Zn(L21)(H2O)] | 65 | 2.89 | 126.00 | ||
2b | |||||
66 = [Zn(L22)] | 66 | 3.10 | 189.00 | ||
2c | |||||
67 = [Zn(L23)] | 67 | 16.10 | NA | ||
2d | |||||
68 = [Zn2(L24)2(Cl)2] | 68 | 4.06 | 86.0 |
Not reported.