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. 2022 Apr 20;12(19):12011–12052. doi: 10.1039/d2ra00067a

α-Glucosidase inhibitory activity of trivalent metal complexes bearing picolinic acid (PicAs) and hydroxamic acid.

Entry Compounds Structure number IC50 (μM) Ref.
1 graphic file with name d2ra00067a-u60.jpg L29 NA 85 a
graphic file with name d2ra00067a-u61.jpg L30 NA
graphic file with name d2ra00067a-u62.jpg L31 NA
graphic file with name d2ra00067a-u63.jpg L32 NA
2 graphic file with name d2ra00067a-u64.jpg 64 b
102 = [Fe(L11)3] 102 446.2
3 graphic file with name d2ra00067a-u65.jpg
103 = [Fe(L11)(L12)(NO3)2] 103 492.3 62 b
4 graphic file with name d2ra00067a-u66.jpg 84 b
104 = [Cr(L17)3] 104 >600
5 graphic file with name d2ra00067a-u67.jpg 66 c
105 = [Cr(L11)2(NCS)(H2O)] 105 >600
6 graphic file with name d2ra00067a-u68.jpg 64 b
106 = [Cr(L11)2(H2O)2] 106 164.87
7 graphic file with name d2ra00067a-u69.jpg 85 a
107 = [Cr(L29)2(H2O)2] 107 28.7
108 = [Cr(L30)2(H2O)2] 108 69.28
109 = [Cr(L31)2(H2O)2] 109 355.9
110 = [Cr(L32)2(H2O)2] 110 169.5
a

Acarbose as the reference drug (IC50 = 418 ± 0.55 μM).

b

Genistein as the reference drug (IC50 = 16.57 ± 0.23 μM).

c

Genistein as the reference drug (IC50 = 7.85 ± 0.87 μM).