α-Glucosidase inhibitory activity of trivalent metal complexes bearing picolinic acid (PicAs) and hydroxamic acid.
Entry | Compounds | Structure number | IC50 (μM) | Ref. |
---|---|---|---|---|
1 | L29 | NA | 85 a | |
L30 | NA | |||
L31 | NA | |||
L32 | NA | |||
2 | 64 b | |||
102 = [Fe(L11)3] | 102 | 446.2 | ||
3 | ||||
103 = [Fe(L11)(L12)(NO3)2] | 103 | 492.3 | 62 b | |
4 | 84 b | |||
104 = [Cr(L17)3] | 104 | >600 | ||
5 | 66 c | |||
105 = [Cr(L11)2(NCS)(H2O)] | 105 | >600 | ||
6 | 64 b | |||
106 = [Cr(L11)2(H2O)2] | 106 | 164.87 | ||
7 | 85 a | |||
107 = [Cr(L29)2(H2O)2] | 107 | 28.7 | ||
108 = [Cr(L30)2(H2O)2] | 108 | 69.28 | ||
109 = [Cr(L31)2(H2O)2] | 109 | 355.9 | ||
110 = [Cr(L32)2(H2O)2] | 110 | 169.5 |
Acarbose as the reference drug (IC50 = 418 ± 0.55 μM).
Genistein as the reference drug (IC50 = 16.57 ± 0.23 μM).
Genistein as the reference drug (IC50 = 7.85 ± 0.87 μM).