α-Glucosidase inhibitory activity of tetravalent metal complexes bearing hydrazide, picolinic acid (PicAs), and Schiff base ligands.

Entry	Compounds	Structure number	IC50 (μM)	Ref.
1		L33	Not reported	94 a
		L34	Not reported	94 a
		L35	NA	93 b
		L36	NA	93 b
		L37	NA	93 b
		L38	NA	93 b
		L39	NA	93 b
		L40	NA	93 b
		L41	NA	93 b
		L42	NA	93 b
		L43	NA	93 b
		L44	NA	93 b
		L45	Not reported	95 c
		L46	Not reported	95 c
		L47	Not reported	95 c
		L48	Not reported	95 c
		L49	Not reported	95 c
		L50	Not reported	95 c
		L51	Not reported	95 c
		L52	Not reported	96 a
		L53	Not reported	96 a
		L54	Not reported	96 a
		L55	22.72	96 a
		L56	Not reported	96 a
		L57	Not reported	96 a
		L58	74.11	96 a
		L59	245	96 a
2				94 a
	111 = [VO(L33)(L34)]	111	14.75
3				93 b
3a
	112 = [(VO)2(L35)2(H2O)2]·SO42−	112	10.70
3b
	R = Br, OCH3, I, NH2, NO2
	113 = [(VO)2(L36)2(H2O)2]	113	67.00
	114 = [(VO)2(L37)2(H2O)2]	114	20.10
	115 = [(VO)2(L38)2(H2O)2]	115	0.68
	116 = [(VO)2(L39)2(H2O)2]	116	12.50
	117 = [(VO)2(L40)2(H2O)2]	117	800
	118 = [(VO)2(L41)2(H2O)2]	118	758
	119 = [(VO)2(L42)2(H2O)2]	119	38.00
	120 = [(VO)2(L43)2(H2O)2]	120	13.50
	121 = [(VO)2(L44)2(H2O)2]	121	16.40
4				62 d
	122 = [VO(L11)(L12)]	122	>600
5				84 d
	123 = [VO(L17)2]	123	>600
6				95 c
	R1 = H, NO2, CH3
	R2 = H, CH3
	124 = [VO(L45)(L46)]	124	Not reported clearly
	125 = [VO(L45)(L47)]	125	Not reported clearly
	126 = [VO(L45)(L48)]	126	Not reported clearly
	127 = [VO(L45)(L49)]	127	Not reported clearly
	128 = [VO(L45)(L50)]	128	Not reported clearly
	129 = [VO(L45)(L51)]	129	Not reported clearly
7				96 a
	X = H, Cl, OCH3, NO2
	Y = H, Br
	130 = [VO(L52)2]	130	2.11
	131 = [VO(L53)2]	131	13.12
	132 = [VO(L54)2]	132	1.26
	133 = [VO(L55)2]	133	1.26
	134 = [VO(L56)2]	134	16.92
	135 = [VO(L57)2]	135	Not reported
	136 = [VO(L58)2]	136	92.43
	137 = [VO(L59)2]	137	31.10

^aAcarbose as the reference drug (IC₅₀ = 18.59 μM).

^bAcarbose as the reference drug (IC₅₀ = 780 ± 0.28 μM).

^cNot reported.

^dGenistein as the reference drug (IC₅₀ = 16.75 ± 0.23 μM).