FIGURE 2.

CYP3A5*3*6*7 metabolic composite scoring algorithm. Any of the three single nucleotide polymorphisms (SNPs), CYP3A5*3, CYP3A5*6, and CYP3A5*7 independently result in loss of protein gene expression from the carrying chromosome. Metabolic composite status for each patient based upon the combined allelic status from each chromosome is summarized in (A–D). (A) Depicts an extensive metabolizer with two completely functional genes. (C) Depicts one possible example of a poor metabolizer: individuals who carry a loss‐of‐function allele on both chromosomes. Similarly, (B and D) represent examples of possible intermediate metabolizers: individuals who are heterozygous at one or more loci. Note that for the double heterozygote case (D), the genotyping assay used could not differentiate between cis‐ and trans‐SNPs; therefore, the trans condition was conservatively assigned the intermediate metabolizer though such individuals would have no functional enzyme. ⁴³ (Permission to reproduce this figure was granted by Journal of Clinical Pharmacology)