TABLE 1.
Demographics by race and sex groups (n = 65)
|
Parameter Mean (SD) |
Black females (n = 13) | Black males (n = 20) | White females (n = 16) | White males (n = 16) | p‐Values for the effect of | Significant pairwise comparisons (Tukey adjusted) | ||
|---|---|---|---|---|---|---|---|---|
| Race | Sex | Race × Sex interaction | ||||||
| Age (years) b | 47.9 (9.9) | 47.1 (12.5) | 50.4 (13.6) | 50.4 (10.3) | 0.350 | 0.902 | 0.780 | — |
| Time Post‐Transplant (years) a | 2.99 (2.20) | 2.59 (1.68) | 3.06 (2.89) | 3.59 (3.40) | 0.589 | 0.963 | 0.644 | — |
| Total body weight (kg) a | 87.9 (24.2) | 91.6 (18.8) | 73.1 (16.0) | 94.8 (17.6) | 0.244 | 0.007 | 0.064 |
BM vs. WF p = 0.021 WM vs. WF p = 0.008 |
| BMI (kg/m2) a | 32.5 (7.9) | 30.1 (6.1) | 28.1 (6.0) | 30.3 (4.2) | 0.250 | 0.861 | 0.124 | — |
| Albumin (g/dl) | 4.02 (0.33) | 4.24 (0.25) | 4.04 (0.28) | 4.17 (0.29) | 0.676 | 0.019 | 0.571 | — |
| Glucose (mg/dl) c | 121.7 (76.8) | 114.2 (62.3) | 92.8 (28.8) | 133.8 (95.2) | 0.380 | 0.058 | 0.278 | — |
| Total cholesterol (mg/dl) a | 161.6 (20.3) | 157.7 (59.3) | 163.8(34.3) | 144.4 (34.2) | 0.550 | 0.076 | 0.563 | — |
| Low‐density Lipoprotein (mg/dl) b | 82.1 (19.0) | 76.7 (30.9) | 86.9 (31.6) | 75.6 (30.9) | 0.887 | 0.183 | 0.757 | — |
| High‐density Lipoprotein (mg/dl) b | 56.9 (12.9) | 45.3 (12.8) | 54.6 (15.0) | 42.5 (13.4) | 0.403 | <0.001 | 0.903 |
WF vs. WM p = 0.055 BF vs. WM p = 0.023 |
| Triglycerides (mg/dl) b | 113.3 (43.03) | 188.8 (204.2) | 111.1 (43.8) | 132.1(51.4) | 0.779 | 0.142 | 0.830 | — |
| White blood cells (×103 cells/mm3) a | 5.64 (2.10) | 4.84 (1.40) | 4.93 (1.49) | 5.93 (2.62) | 0.752 | 0.895 | 0.126 | — |
| Neutrophils (×103 cells/mm3) a | 3.55 (1.66) | 3.16 (1.25) | 3.24 (1.23) | 4.19 (2.19) | 0.368 | 0.581 | 0.163 | — |
| Lymphocytes (×103cells/mm3) b | 1.39 (0.44) | 0.95 (0.48) | 1.02 (0.58) | 1.00 (0.39) | 0.215 | 0.061 | 0.065 | BF vs. BM p = 0.047 |
| Platelets (cells × 106) b | 207.7 (35.6) | 185.9 (39.3) | 216.3 (70.1) | 186.6 (50.8) | 0.934 | 0.044 | 0.833 | — |
| Hemoglobin (g/dl) b | 11.19 (0.88) | 12.73 (1.20) | 11.62 (0.84) | 13.43 (1.37) | <0.046 | <0.001 | 0.781 |
BF vs. BM p < 0.001 BF vs. WM p < 0.001 BM vs. WF p = 0.021 WF vs. WM p < 0.001 |
| Serum creatinine (mg/dl) b | 1.52 (0.54) | 1.65 (0.37) | 1.22 (0.28) | 1.26(0.29) | <0.001 | 0.213 | 0.459 |
BM vs. WF p = 0.003 BM vs. WM p = 0.008 |
| eGFR (ml/min/1.73 m2) | 49.9 (17.7) | 57.4 (13.4) | 49.8 (11.5) | 64.5 (16.2) | 0.343 | 0.003 | 0.379 |
BF vs. WM p = 0.044 WF vs. WM p = 0.034 |
| Mycophenolic acid study dose (mg) | 636.9 (157.9) | 639.0 (222.2) | 562.5 (159.3) | 663.8 (108.4) | 0.520 | 0.224 | 0.289 | — |
| Tacrolimus study dose a (mg) | 5.1 (1.7) | 3.7 (1.6) | 2.7 (1.2) | 2.2 (0.7) | <0.001 | 0.020 | 0.262 |
BF vs. WF p < 0.001 BF vs. WM p = 0.001 BM vs. WM p = 0.008 BF vs. BM p = 0.073 |
Data displayed as mean (standard deviation). Significant p values are denoted by bold type.
Abbreviations: B, Blacks; BMI, body mass index; eGFR, estimated glomerular filtration rate; F, females; M, males; SD, standard deviation; W, White.
Parameters that were log transformed during statistical analysis.
Square root transformation of parameter.
Inverse transformation of parameter.