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. Author manuscript; available in PMC: 2022 Nov 4.
Published in final edited form as: Mol Cell. 2021 Sep 13;81(21):4398–4412.e7. doi: 10.1016/j.molcel.2021.08.019
Drosophila Motif Consensus sequence TSS Search window
TATA box STATAWAWR (Ohler et al., 2002) −110 to +1
Initiator +G (InrG) TCAGTY (Ohler et al., 2002; Hendrix et al., 2008) −5 to −1
Initiator -G (Inr) TCAHTY (Ohler et al., 2002; Hendrix et al., 2008; Shao et al., 2019) −5 to −1
TCT motif YYCTTTYY (Parry et al., 2010) −5 to −1
Downstream promoter element (DPE) KCGGTTSK (Ohler et al., 2002) +1 to +50
Motif ten element (MTE) CSARCSSA (Lim et al., 2004) +1 to +50
Pause Button (PB) KCGRWCG (Hendrix et al., 2008) +1 to +50
Human Motif Consensus sequence TSS Search window

TATA box TATAWAAR (Carninci et al., 2006; Ponjavic et al., 2006; Juven-Gershon et al., 2008) −110 to +1
Initiator YYANWYY (Javahery et al., 1994) −5 to −1
TCT motif YCTYTYY (Parry et al., 2010) −5 to −1
Downstream promoter element (DPE) RGWYV (Burke and Kadonaga, 1996) +1 to +50
Motif ten element (MTE) CSARCSSA (Lim et al., 2004) +1 to +50