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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: ACS Nano. 2022 Jan 31;16(2):1940–1953. doi: 10.1021/acsnano.1c05505

Figure 2.

Figure 2.

A burst of RT primes GBM for enhanced uptake of targeted RGD-EV. (A) Fluorescence image of Cy5.5-labeled RGD-EV; scale bar, 2 μm. (B,C) Mice-bearing GBM were irradiated (or not) and 3 days later injected with Cy5.5-labeled control EVs or RGD-EV. Representative NIRF images (overlaid with bright-field) of mice brain, 24 h post-EV administration (B). Quantification of fluorescence intensity in the tumor region (C); Data presented as mean ± SEM (n = 4); **P < 0.01, ***P < 0.001 by one-way ANOVA. (D) GBM-bearing mice were irradiated and injected with tdTomato-labeled EVs or RGD-EV. Representative fluorescence images of EVs (red) in GBM (GFP) 6 h post-EV administration; blue indicates nuclei; scale bar, 50 μm.