Table 4.
Effect of the STK11 SNP on clinical parameters in White PwMS
| VALOMS White STK11 SNP allele |
UCSF White STK11 SNP allele |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Group | Variable | n | C/C | n | C/T | n | C/C | n | C/T |
| M&F | EDSS | 52 | 4.2 ± 0.3 | 5 | 3.9 ± 1.3 | 577 | 2.8 ± 0.1 | 65 | 2.3 ± 0.2 a |
| AgeSx | 52 | 35.6 ± 1.6 | 5 | 33.6 ± 3.4 | 581 | 32.8 ± 0.4 | 66 | 32.1 ± 1.1 | |
| AgeDx | 52 | 42.1 ± 1.4 | 5 | 37.4 ± 2.5 | n/a | n/a | |||
| MSSS | 52 | 4.9 ± 0.4 | 5 | 4.3 ± 0.4 | 577 | 3.5 ± 0.1 | 66 | 3.0 ± 0.3 | |
| M | EDSS | 40 | 4.3 ± 0.3 | 4 | 3.0 ± 1.2 | 189 | 3.0 ± 0.1 | 19 | 2.1 ± 0.3 a |
| AgeSx | 40 | 37.0 ± 1.9 | 4 | 35.0 ± 4.0 | 190 | 33.4 ± 0.7 | 19 | 29.3 ± 2.4 b | |
| AgeDx | 40 | 42.2 ± 1.7 | 4 | 39.5 ± 2.6 | n/a | n/a | |||
| MSSS | 40 | 5.2 ± 0.4 | 4 | 3.0 ± 1.2 | 189 | 3.6 ± 0.2 | 19 | 3.2 ± 0.6 | |
| F | EDSS | 12 | 3.9 ± 0.6 | 1 | 7.5 | 388 | 2.7 ± 0.1 | 46 | 2.4 ± 0.2 |
| AgeSx | 12 | 30.8 ± 3.0 | 1 | 28 | 391 | 32.5 ± 0.5 | 47 | 33.2 ± 1.2 | |
| AgeDx | 12 | 41.5 ± 2.3 | 1 | 29 | n/a | n/a | |||
| MSSS | 12 | 3.8 ± 0.8 | 1 | 9.7 | 388 | 3.5 ± 0.1 | 47 | 2.9 ± 0.3 | |
| SPMS | EDSS | 26 | 5.3 ± 0.4 | 1 | 6.5 | ||||
| AgeSx | 26 | 37.2 ± 2.1 | 1 | 28 | |||||
| AgeDx | 26 | 44.5 ± 1.6 | 1 | 35 | |||||
| MSSS | 26 | 5.8 ± 0.5 | 1 | 6.3 | |||||
| RRMS | EDSS | 26 | 3.1 ± 0.3 | 4 | 3.3 ± 1.4 | ||||
| AgeSx | 26 | 33.9 ± 2.4 | 4 | 35.0 ± 4.0 | |||||
| AgeDx | 26 | 39.7 ± 2.2 | 4 | 38.0 ± 3.7 | |||||
| MSSS | 26 | 3.9 ± 0.5 | 4 | 3.9 ± 2.0 | |||||
a,
P<0.05
b,
P=0.088.
EDSS, expanded disability severity scale; AgeSx, age at symptom onset; AgeDx, age at diagnosis; MSSS, multiple sclerosis severity score; RR, relapsing remitting; SP, secondary progressive.