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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: Neurosci Lett. 2021 Apr 20;755:135895. doi: 10.1016/j.neulet.2021.135895

Fig. 4.

Fig. 4.

Demonstration of selective enrichment of BF cholinergic neurons with p75NTR and mediated by this receptor internalization of Aβ peptide in cholinergic neurons with sorting to acidifying late endosomes. (A) Confocal images of rat BF cholinergic area with neurons labelled using ChAT markers specific for cholinergic neurons and IgG-192-CY3 labelling p75NTR enriched neurons. Note a high degree of colocalization. Adapted with permission [103]. (B) Cholinergic neurons in primary neuronal cultures after exposure to Alexa488 labelled Aβ and IgG-192-CY3 (left) and staining with an anti-RAB-7 antibody specific for late endosomes (right). (C) Cholinergic neurons in primary neuronal cultures after exposure to IgG-192-CY3 and core streptavidin fused with heavy chain of tetanus toxin, know also to bind to p75 NTR (CS-TeTX-Hc). Courtesy of I. Antyborzec (image taken from Ph.D. thesis).