Table 1. Priority research themes, activities & timescales.

Research theme	Activity	Timescale
Characterising spatiotemporal variation in treatment responses	•   Development of an efficacy explorer to map responses in space and time •   Engagement to increase research and data collection on anthelminthic quality	Short-term Mid-/long-term
Improving evidence base for treatment regimens	•   Individual participant data (IPD) meta-analyses on drug combinations for treating hookworm & Trichuris trichiura (whipworm) •   IPD meta-analyses on effect of dose and frequency of administration on efficacy of praziquantel (e.g. 40 mg/kg vs. 60 mg/kg in single or multiple doses)	Short-/mid-term Short-/mid-term
Evaluating new antigen- detection & molecular diagnostics	•   Define reference range of responses to praziquantel measured using antigen detection methods (CCA or CAA) •   Comparison of assays and laboratory protocols for molecular identification of soil-transmitted helminth infection and promotion of standardised approaches	Short-/mid-term Short-/mid-term
Standardising study design and reporting	•   Development of a case record form incorporating the data standard developed by the Clinical Data Interchange Standards Consortium (CDISC) •   Engagement to foster adoption of standardised protocols and reporting	Short-term Mid-/long-term
Medicine safety in pregnancy	•   IPD meta-analyses of safety (and efficacy) of praziquantel and benzimidazoles in pregnant and breastfeeding women	Short-/mid-term
Medicine formulation for preschool-age children	•   Collation, curation & standardisation of phase III clinical trial data on paediatric praziquantel formulation	Short-/mid-term
Analytical approaches	•   Testing, comparison and recommendations on optimal statistical approaches for IPD (meta-) analyses using ‘gold standard’ datasets	Short-/mid-term