An official website of the United States government
Here's how you know
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Fig. 1. Analogs of armeniaspirol to probe antibiotic activity via inhibition of ClpXP and ClpYQ (A) 5-chloroarmeniaspirol inhibits the ATP-dependent proteases ClpXP and ClpYQ in Gram-positive bacteria, which dysregulates the divisome and leads to cell division arrest. (B) Summary of structure–activity relationships for armeniaspirol. Functional groups highlighted in blue are essential for antibiotic activity. R indicates sites amenable to substitution. (C) 5-chloroarmeniaspirol sites R1 and R2 were selected for detailed structure–activity relationship.