Fig. 2. Armeniaspirol analogues. (A) Synthetic route installing the hexyl chain for the starting material used for all series 1 analogues. Reagents and conditions are as follows a) n-BuLi, Br2 b) Pd(OAc)2, SPhos, K3PO4. (B) Synthetic route generating series 1 and 2 analogues from dimethyl-2-methylresorcinol and dimethyl-2-hexylresorcinol. Reagents and conditions are as follows a) SnCl4 b) BBr3 c) NCS d) NEt3 e) NaH f) BBr3 (C) structures of series 1 and 2 analogues used in this study.
