MIC evaluation of analogues 1–14 against a panel of Gram positive and negative bacteria.
| Minimum inhibitory concentration (μg mL−1) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
| Gram-positive | ||||||||||||||
| S. aureus IA116-USA100 | 4 | 1 | 8 | 4 | 1 | 2 | 1 | 1 | >32 | 4 | 2 | >32 | >32 | 16 |
| S. aureus MN8-USA200 | 4 | 1 | 16 | 4 | 1 | 2 | 0.5 | 0.5 | >32 | 4 | 2 | >32 | >32 | 16 |
| S. aureus LAC-Fitz-USA300 | 4 | 1 | 16 | 4 | 1 | 2 | 0.5 | 0.5 | >32 | 4 | 1 | >32 | 32 | 16 |
| S. aureus MW2-USA400 | 4 | 1 | 8 | 4 | 2 | 2 | 0.5 | 0.5 | >32 | 8 | 2 | >32 | 32 | 16 |
| E. faecalis NJ3 | 8 | 2 | 8 | 8 | 2 | 2 | 1 | 1 | >32 | 8 | 0.5 | >32 | >32 | 32 |
| Gram-negative | ||||||||||||||
| P. aeruginosa PA01 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |