Table 3.

Multivariate logistic regression analyses for M-CHAT/F^a completion and M-CHAT/F positivity adjusted for demographic factors, COVID-19 Cohort,^b as well as interaction terms between demographics and cohort

	M-CHAT/F Completion		M-CHAT/F Positivity
	Adjusted Odds Ratio(95% Confidence Intervals, CI)	P-Value	Adjusted Odds Ratio(95% CI)	P-Value
Cohort Pre-COVID-19 Cohort COVID-19 Cohort	Reference 0.69 (0.62–0.76)	Reference <0.0001	Reference 1.08 (0.91-1.27)	Reference 0.38
Sex Female Male	Reference 0.98 (0.91–1.06)	Reference 0.62	Reference 1.63 (1.28-1.80)	Reference <0.0001
Interaction between chort and sex Female*COVID-19 cohort Male*COVID-19 cohort	Reference 1.05 (0.94–1.16)	Reference 0.40	Reference 0.94 (0.82-1.09)	Reference 0.44
Race and ethnicity Asian Black, Non-Hispanic Hispanic or Latino Other White, Non-Hispanic	0.53 (0.45–0.63) 0.51 (0.45–0.56) 0.76 (0.5–0.89) 0.69 (0.61–0.77) Reference	<0.0001 <0.0001 <0.001 <0.0001 Reference	2.81 (2.25–3.50) 2.33 (2.03–2.67) 2.28 (1.90–2.74) 1.66 (1.42–1.94) Reference	<0.0001 <0.0001 <0.0001 <0.0001 Reference
Interaction between Cohort and Race and Ethnicity Asian*COVID-19 cohort Black, Non-Hispanic*COVID-19 cohort Hispanic or Latino*COVID-19 cohort Other *COVID-19 cohort White, Non-Hispanic*COVID-19 cohort	1.37 (1.07–1.76) 1.17 (1.01–1.37) 1.00 (0.80–1.24) 1.19 (1.01–1.39) Reference	0.01 0.04 1.00 0.03 Reference	0.95 (0.92–1.35) 1.11 (0.91–1.35) 0.91 (0.70–1.19) 1.03 (0.82–1.29) Reference	0.76 0.31 0.50 0.81 Reference
Preferred language English Spanish	Reference 0.56 (0.44–0.72)	Reference <0.0001	Reference 1.19 (0.90–1.56)	Reference 0.22
Interaction between cohort and preferred language English*COVID-19 cohort Spanish*COVID-19 cohort	Reference 0.82 (0.59–1.15)	Reference 0.25	Reference 0.92 (0.61–1.38)	Reference 0.69
Insurance Private Public	Reference 0.88 (0.81–0.97)	Reference 0.008	Reference 2.78 (2.48–3.12)	Reference <0.0001
Interaction between cohort and insurance Private*COVID-19 cohort Public*COVID-19 cohort	Reference 1.03 (0.91–1.17)	Reference 0.64	Reference 1.00 (0.85–1.18)	Reference 0.98

Bolded values indicate statistically significant differences between proportions in COVID-19 cohort compared to pre-COVID-19 cohort.

^aM-CHAT/F indicates Modified Checklist for Autism in Toddlers with Follow-up.

^bThe COVID-19 Cohort (eligible children presenting for well-child care between March 1, 2020 and February 28, 2021) was compared to the Pre-COVID-19 Cohort (children presenting for well-child care between March 1, 2019 and February 29, 2020; reference group).