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. 2022 Apr 20;17(4):e0265928. doi: 10.1371/journal.pone.0265928

Table 2. Least square means and mean difference of change on the physical and mental component summary of the HRQoL for the combined panels analysis (2005–2015) and the significance of the difference from the uni- and multivariate D-I-D analysis.

Overall Change Received antidepressant medication
Yes No p-value*
Year Baseline Follow-up Mean Difference Baseline Follow-up Mean Difference Baseline Follow-up Mean Difference
Univariate
    PCS 44.52 44.18 - 0.34 43.58 43.23 - 0.35 45.72 45.38 - 0.34 0.9595
    MCS 42.08 43.30 1.22 41.03 42.31 1.28 43.41 44.54 1.13 0.5284
Multivariate
    PCS 44.52 44.18 - 0.34 42.50 41.85 - 0.65 43.86 43.31 - 0.55 0.6405
    MCS 42.08 43.30 1.22 40.32 41.50 1.18 42.99 43.92 0.93 0.3191

Results were presented as least square means from baseline and follow-up for both groups and mean difference within each group.

Age, gender, race, ethnicity, marital status, poverty level, and insurance coverage were included in the multivariate analysis to adjust for the effect of these significant factors between the cohort on the outcomes’ variables.

* p-value <0.05 was considered statistically significant and numbers in bold indicate significant results.