Table 3. Least square means and mean difference of change on the physical component summary of the HRQoL (univariate analysis).

	Overall Change			Received antidepressant medication
				Yes			No
Year	Baseline	Follow-up	Mean Difference	Baseline	Follow-up	Mean Difference	Baseline	Follow-up	Mean Difference	p-value*
2005	43.59	42.95	- 0.64	43.25	42.89	- 0.36	44.05	43.05	- 1.00	0.3418
2006	44.38	44.00	- 0.38	42.74	42.38	- 0.36	46.58	46.17	- 0.41	0.9297
2007	45.09	44.72	- 0.37	44.12	44.24	0.12	46.54	45.44	- 1.10	0.1313
2008	44.12	43.57	- 0.55	43.89	43.29	- 0.60	44.42	43.95	- 0.47	0.8284
2009	44.40	43.81	- 0.59	43.09	42.93	- 0.16	46.08	44.96	- 1.12	0.1397
2010	44.29	43.71	- 0.58	43.53	42.85	- 0.68	45.24	44.78	- 0.46	0.7443
2011	44.35	43.99	- 0.36	43.86	43.57	- 0.29	44.94	44.51	- 0.43	0.8067
2012	44.02	44.08	0.06	43.19	43.15	- 0.04	45.04	45.21	0.17	0.7235
2013	44.65	44.49	- 0.16	43.58	43.26	- 0.32	45.87	45.90	0.03	0.5488
2014	45.13	44.95	- 0.18	43.97	43.18	- 0.79	46.51	47.06	0.55	0.0265
2015	45.29	45.00	- 0.29	43.91	43.65	- 0.26	46.99	46.66	- 0.33	0.9039

Results were presented as least square means from baseline and follow-up for both groups and mean difference within each group.

* p-value <0.05 was considered statistically significant and numbers in bold indicate significant results.