Table 4. Least square means and mean difference of change on the mental component summary of the HRQoL (univariate analysis).

	Overall Change			Received antidepressant medication
				Yes			No
Year	Baseline	Follow-up	Mean Difference	Baseline	Follow-up	Mean Difference	Baseline	Follow-up	Mean Difference	p-value*
2005	42.07	42.86	0.79	40.21	41.58	1.37	44.59	44.6	0.01	0.1109
2006	41.39	42.75	1.36	39.88	41.39	1.51	43.41	44.56	1.15	0.6742
2007	41.97	43.38	1.41	40.96	42.59	1.63	43.48	44.56	1.08	0.6029
2008	41.35	42.58	1.23	40.16	41.13	0.97	42.92	44.49	1.57	0.4824
2009	41.64	43.11	1.47	40.67	41.81	1.14	42.87	44.78	1.91	0.3659
2010	41.92	42.85	0.93	40.85	41.78	0.93	43.25	44.16	0.91	0.9862
2011	41.47	42.61	1.14	40.83	41.68	0.85	42.25	43.75	1.5	0.4005
2012	42.11	43.85	1.74	41.34	42.72	1.38	43.04	45.22	2.18	0.3022
2013	42.7	43.57	0.87	42.02	43.47	1.45	43.48	43.68	0.2	0.0894
2014	43.14	44.26	1.12	42.06	43.75	1.69	44.42	44.87	0.45	0.126
2015	42.61	43.88	1.27	41.56	42.8	1.24	43.89	45.21	1.32	0.9251

Results were presented as least square means from baseline and follow-up for both groups and mean difference within each group.

* p-value <0.05 was considered statistically significant and numbers in bold indicate significant results.