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. 2022 Apr 8;18(4):e1009990. doi: 10.1371/journal.ppat.1009990

Fig 3. Ad26.COV2.S vaccination attenuates signatures of complement system activation and coagulation cascade associated with severe COVID-19.

Fig 3

(A) Sample-enrichment analysis (SLEA) of pathways of thrombosis-associated pathways decreased in Ad26 vaccinated animals at 4 dpi (in pink and blue) compared to sham-unvaccinated animals (in green). Heatmap presenting the SLEA z-score of each of these pathways. SLEA scores represent the mean expression of all significant genes within each pathway for each animal. (B) Heatmaps of the normalized expression of the leading genes contributing to the enrichment of thrombosis-associated pathways increased by SARS-CoV-2 in sham animals (in green) and decreased in Ad26 vaccinated hamsters (in pink and blue) at 4 dpi. (C) Radar plot showing the GSEA normalized enrichment score (NES) of thrombosis-associated pathways decreased in Ad26 vaccinated hamsters in blue and pink compared to sham unvaccinated animals in green. (D) Correlation matrix plot showing the Spearman correlations of thrombosis-associated pathways at 4 dpi with viral loads in hamster’s lung and nares at 4 dpi and neutralizing and binding antibody titers at weeks 2–4 post-vaccination. Negative correlations were shown in cyan, and positive correlations were shown in pink.