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. 2022 Apr 8;18(4):e1010458. doi: 10.1371/journal.ppat.1010458

Fig 8. Functional module involving TCS01 in Streptococcus pneumoniae.

Fig 8

The BceAB/TCS01 module is able to sense the presence of antimicrobial peptides targeting undecaprenylpyrophosphate (UPP) or lipid II (step 1). The AMPs presumably bind to the extracellular domain of BceAB and stimulate the ATPase or GTPase activity of the transporter, triggering or enhancing the phosphorylation of TCS01 (steps 2 and 3). Consequently, the RR upregulates the operon containing the bceAB genes but does not regulate the tcs01 operon (step 4). The overexpression of BceAB mediates antimicrobial peptide resistance (step 5).