Figure 2. Diet-specific effects of a fiber vs. fermented food intervention on the host and microbiome.
(A) Accuracy of leave-one-out cross-validation (LOOCV) of random forest models predicting diet group; separate models using host-derived data (white bars) or microbe-derived data (black bars), using parameter changes from baseline to end of maintenance as model features. Recursive feature elimination chose the minimum number of parameters needed for maximum accuracy.
(B) Differences in myosin-1, model feature selected for host proteomics model.
(C) Differences in rank-order change of Lachnospira, model feature selected for 16S amplicon sequence variants (ASVs) model. Purple, fermented group; green, fiber group.