Figure 8. Basket displacement promotes ageing (A) Example images of the same young and old wild-type cell in a trap of the yeast ageing chip.

The age of the cell is indicated, scale bar is 5 µm. (B) The design of the array with improved traps in the ageing chip. One single trap is highlighted to show its dimensions. The arrow shows the direction of the medium flow. (C) The lifespan curve for nup60Δ and nup60-K467R compared to a wild-type strain, plotted with 95% confidence interval limits. The p-value stands for Log-Rank test between nup60Δ or nup60-K467R with the wild-type strain. (D) Model depicting that DNA circle accumulation affects the organization of the NPC via a SAGA-mediated basket displacement.