Table 3. Summary of expression patterns for all knock-in lines (related to Figures 3—5).

Summarized here are all of the olfactory sensory neuron (OSN) classes innervating the 58 antennal lobe glomeruli^†; their corresponding sensilla and tuning receptors; the previously reported (original) co-receptors they express; and whether or not each of the co-receptor knock-in lines labels those glomeruli. Variable indicates that the glomerulus was labeled in <50% of brains examined in the given knock-in line. Sensilla or glomeruli that have been renamed or reclassified have their former nomenclature listed in parentheses. Question marks indicate expression that has been reported but not functionally validated. * See also Figure 3—source data 1 and Figure 3—source data 2.

Glomerulus†	Sensillum	Tuning receptor(s)	Original co-receptor(s)	Orco-T2A-QF2	Ir8a-T2A-QF2	Ir76b-T2A-QF2	Ir25a-T2A-QF2	References
D	Ab9A	Or69aA, Or69aB	Orco	Yes	Variable	No	No	Couto et al., 2005; Fishilevich and Vosshall, 2005
DA1	At1A	Or67d	Orco	Yes	No	Variable	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005; Kurtovic et al., 2007
DA2	Ab4B	Or56a, Or33a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
DA3	Ai2B (At2B)	Or23a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005; Lin and Potter, 2015
DA4l	Ai3C (At3C)	Or43a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005; Lin and Potter, 2015
DA4m	Ai3B (At3B)	Or2a	Orco	Yes	No	No	Yes	Couto et al., 2005; Lin and Potter, 2015
DC1	Ai3A (At3A)	Or19a, Or19b	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005; Lin and Potter, 2015
DC2	Ai1A (Ab6A)	Or13a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005; Lin and Potter, 2015
DC3	Ai2A (At2A)	Or83c	Orco	Yes	No	Yes	Variable	Couto et al., 2005; Fishilevich and Vosshall, 2005; Lin and Potter, 2015
DL1	Ab1D	Or10a, Gr10a	Orco	Yes	Yes	Yes	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
DL3	At4B	Or65a, Or65b, Or65c	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
DL4	Ab10B	Or49a, Or85f	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
DL5	Ab4A	Or7a	Orco	Yes	No	No	Variable	Couto et al., 2005
DM1	Ab1A	Or42b	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
DM2	Ab3A	Or22a, Or22b	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
DM3	Ab5B	Or47a, Or33b	Orco	Yes	No	No	No	Couto et al., 2005; Fishilevich and Vosshall, 2005
DM4	Ab2A	Or59b	Orco	Yes	No	No	Yes	Couto et al., 2005
DM5	Ab2B	Or85a, Or33b	Orco	Yes	No	No	No	Couto et al., 2005; Fishilevich and Vosshall, 2005
DM6	Ab10A	Or67a	Orco	Yes	No	No	Yes	Couto et al., 2005
VA1d	At4C	Or88a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VA1v	At4A	Or47b	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VA2	Ab1B	Or92a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VA3	Ab9B	Or67b	Orco	Yes	Yes	Yes	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VA4	Pb3B	Or85d	Orco	Yes	No	No	Yes	Couto et al., 2005
VA5	Ai1B (Ab6B)	Or49b	Orco	Yes	Yes	Yes	Yes	Couto et al., 2005; Lin and Potter, 2015
VA6	Ab5A	Or82a	Orco	Yes	Yes	Yes	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VA7l	Pb2B	Or46a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VA7m	UNK	UNK	Orco	Yes	No	Variable	Yes	Couto et al., 2005
VC1	Pb2A	Or33c, Or85e	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VC2	Pb1B	Or71a	Orco	Yes	No	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VC4	Ab7B	Or67c	Orco	Yes	No	Yes	Yes	Couto et al., 2005
VM2	Ab8A	Or43b	Orco	Yes	No	No	No	Couto et al., 2005
VM3	Ab8B	Or9a	Orco	Yes	No	No	No	Couto et al., 2005
VM5d	Ab3B	Or85b?, Or98b?	Orco	Yes	Variable	No	Yes	Couto et al., 2005
VM5v	Ab7A	Or98a	Orco	Yes	Yes	No	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005
VM7d	Pb1A	Or42a	Orco	Yes	No	No	Yes	Couto et al., 2005; Endo et al., 2007; Fishilevich and Vosshall, 2005
VM7v (1)	Pb3A	Or59c	Orco	Yes	No	No	Yes	Couto et al., 2005; Endo et al., 2007
VC3	Ac3B	Or35a	Orco, Ir76b	Yes	Yes	Yes	Yes	Couto et al., 2005; Fishilevich and Vosshall, 2005; Silbering et al., 2011
V	Ab1C	Gr21a, Gr63a	N/A	Yes	No	No	Yes	Couto et al., 2005; Jones et al., 2007; Kwon et al., 2007
DC4	Sacculus, chamber III	Ir64a	Ir8a	Variable	Yes	No	Yes	Ai et al., 2013; Ai et al., 2010; Silbering et al., 2011
DL2d	Ac3A	Ir75b	Ir8a	Yes	Yes	No	Yes	Prieto-Godino et al., 2017; Silbering et al., 2011
DL2v	Ac3A	Ir75c	Ir8a	Yes	Yes	No	Yes	Prieto-Godino et al., 2017; Silbering et al., 2011
DP1l	Ac2	Ir75a	Ir8a	Yes	Yes	Yes	Yes	Silbering et al., 2011
DP1m	Sacculus, chamber III	Ir64a	Ir8a	No	Yes	Yes	Yes	Ai et al., 2013; Ai et al., 2010; Silbering et al., 2011
VL2a	Ac4	Ir84a	Ir8a	Yes	Yes	Yes	Yes	Silbering et al., 2011
VL2p	Ac1	Ir31a	Ir8a	No	Yes	Yes	Yes	Silbering et al., 2011
VC5	Ac2	Ir41a	Ir8a, Ir25a, Ir76b	No	Yes	Yes	Yes	Hussain et al., 2016; Min et al., 2013; Silbering et al., 2011
VM1	Ac1	Ir92a	Ir8a, Ir25a, Ir76b	No	Yes	Yes	Yes	Min et al., 2013; Silbering et al., 2011
VM4	Ac4	Ir76a	Ir8a, Ir25a, Ir76b	Yes	Yes	Yes	Yes	Benton et al., 2009; Min et al., 2013; Silbering et al., 2011
VL1	Ac1, Ac2, Ac4	Ir75d	Ir25a	Yes	Yes	Yes	Yes	Silbering et al., 2011
VM6v (VM6)	Ac1	Rh50, Amt	Ir25a	No	Yes (weak)	No	Yes	Chai et al., 2019; Li et al., 2016; Schlegel et al., 2021; Vulpe et al., 2021, this paper
VM6m (new)	Sacculus, chamber III	Rh50, Amt	N/A (this paper)	No	Yes (weak)	No	Yes	Chai et al., 2019; Li et al., 2016; Schlegel et al., 2021; Vulpe et al., 2021, this paper
VM6l* (new)	Sacculus, chamber III	Rh50, Amt	N/A (this paper)	No	Yes (strong)	No	Yes	Chai et al., 2019; Li et al., 2016; Schlegel et al., 2021; Vulpe et al., 2021, this paper
VP1d	Sacculus, chamber II	Ir40a, Ir93a	Ir25a	No	No	No	Yes	Enjin et al., 2016; Frank et al., 2017; Knecht et al., 2017; Knecht et al., 2016; Marin et al., 2020; Silbering et al., 2011
VP1l	Sacculus, chamber I	Ir21a, Ir93a	Ir25a	No	No	No	Yes	Frank et al., 2017; Knecht et al., 2017; Knecht et al., 2016; Marin et al., 2020; Silbering et al., 2011
VP1m	Sacculus, chamber I	Ir68a, Ir93a	Ir25a	No	No	No	Yes	Frank et al., 2017; Knecht et al., 2017; Knecht et al., 2016; Marin et al., 2020; Silbering et al., 2011
VP2	Arista	Gr28b.d, Ir93a	Ir25a	No	No	No	Yes	Enjin et al., 2016; Frank et al., 2017; Marin et al., 2020; Miwa et al., 2018; Ni et al., 2013
VP3	Arista	Ir21a, Ir93a	Ir25a	No	No	No	Yes	Budelli et al., 2019; Enjin et al., 2016; Frank et al., 2017; Silbering et al., 2011
VP4	Sacculus, chambers I + II	Ir40a, Ir93a	Ir25a	No	No	No	Yes	Enjin et al., 2016; Frank et al., 2017; Knecht et al., 2017; Knecht et al., 2016; Marin et al., 2020; Silbering et al., 2011
VP5	Sacculus, chamber II	Ir68a, Ir93a	Ir25a	No	No	No	Yes	Frank et al., 2017; Knecht et al., 2017; Marin et al., 2020

*VM6l was initially named VC6 in version 1 of our pre-print (Task et al., 2020) but was reclassified using additional data from EM reconstructions in the antennal lobe (AL) and immunohistochemical experiments in the periphery (see Figure 5).

^†The VM6 subdivisions (VM6v, VM6m, VM6l) are separated in this table for clarity but counted together as one glomerulus in accordance with Schlegel et al., 2021.