TABLE 1.
Mortality of Aspergillus-infected rabbits treated with ravuconazole, LY-303366, or amphotericin B
| Group and inoculum (no. of organisms) | Druga (mg/kg/day) | No. dead/no. tested (%)b |
|---|---|---|
| Ravuconazole treatment | ||
| Lethal (106) | None | 4/4 (100) |
| Rav (30) | 0/10* (0) | |
| AmB (1.0) | 0/4* (0) | |
| Sublethal (105) | None | 2/4 (50) |
| Rav (30) | 0/10* (0) | |
| AmB (1.0) | 0/4 (0) | |
| LY-303366 | ||
| Treatment | ||
| Lethal (106) | None | 4/4 (100) |
| LY (5) | 0/7* (0) | |
| LY (10) | 0/8* (0) | |
| AmB (1.0) | 0/4* (0) | |
| Sublethal (105) | None | 3/4 (75) |
| LY (5) | 0/8* (0) | |
| LY (10) | 0/7* (0) | |
| AmB (1.0) | 0/4 (0) | |
| Prophylaxis | ||
| Lethal (106) | None | 4/4 (100) |
| LY (5) | 0/6* (0) | |
| LY (10) | 0/6* (0) | |
| AmB (1.0) | 0/4* (0) | |
| Sublethal (105) | None | 2/4 (50) |
| LY (5) | 0/6 (0) | |
| LY (10) | 0/6 (0) | |
| AmB (1.0) | 0/4 (0) |
a
Rav, ravuconazole; AmB, amphotericin B; LY, LY-303366.
b
*, P < 0.05 compared to controls using Fisher's exact test.