TABLE 4.

Results of organ cultures with intravenously administered LY-303366 begun 48 h prior to challenge

Inoculum	LY-303366 dose, in mg/kg (no. of rabbits cultured)a	Colony counts (mean log10 CFU/g of tissue ± SE)				No. of rabbits with positive cultures/no. cultured
		Liver	Lung	Kidney	Brain	Liver	Lung	Kidney	Brain
Lethal	None (4)	2.99 ± 0.3	3.16 ± 0.2	3.10 ± 0.3	1.86 ± 0.8	4/4	4/4	4/4	3/4
	10 (6)	2.31 ± 0.5	2.84 ± 0.4	1.85 ± 0.6	0.54 ± 0.2	5/6	5/6	3/6	1/6d
	5 (6)	3.18 ± 0.4	3.04 ± 0.4	2.38 ± 0.5	1.81 ± 0.5	6/6	6/6	6/6	5/6
	AmB 1.0 (3)	0.0b	0.36 ± 0.2b	1.31 ± 0.6	0.10 ± 0.08	0/3c	0/3c	1/3	0/3
Sublethal	None (4)	2.82 ± 0.5	1.58 ± 0.2	1.08 ± 0.2	1.01 ± 0.5	3/4	3/4	4/4	1/4
	10 (6)	1.92 ± 0.4	2.12 ± 0.5	1.00 ± 0.4	0.61 ± 0.3	5/6	4/6	5/6	2/6
	5 (6)	2.01 ± 0.6	1.81 ± 0.5	0.95 ± 0.4	0.56 ± 0.3	6/6	3/6	1/6ce	1/6
	AmB 1.0 (4)	0.08 ± 0.07b	0.73 ± 0.3	0.42 ± 0.2	0.23 ± 0.1b	1/4	1/4	2/4	1/4

^aAmB, amphotericin B. 

^bP <0.05 compared to controls (Wilcoxon rank sum test). 

^cP <0.05 compared to controls (Fisher's exact test). 

^dP <0.05 compared to LY-303366 at 5 mg/kg (Fisher's exact test). 

^eP <0.05 compared to LY-303366 at 10 mg/kg (Wilcoxon rank sum test).