TABLE 5.
Serum Aspergillus antigen values for temporarily immunosuppressed rabbits infected with A. fumigatus and treated with ravuconazole
| Inoculum (no. of organisms) | Treatmenta (mg/kg/day) | No. of rabbits with >50 ng of antigen per ml/ no. tested
|
Median ng of antigen/ml (range)
|
||
|---|---|---|---|---|---|
| Day 5b | Day 9c | Day 5b | Day 9c | ||
| Lethal (106) | None | 2/2 | 2/2 | 800 (600–1,000) | 1,000 (1,000) |
| Rav (30) | 0/10 | 0/10 | 0 (0–50) | 0 (0–50) | |
| AmB (1) | 0/4 | 0/4 | 0 (0–33) | 17.5 (0–40) | |
| Sublethal (105) | None | 2/2 | 2/2 | 575 (450–700) | 1,000 (1,000) |
| Rav (30) | 1/10 | 0/9 | 0 (0–100) | 0 (0–50) | |
| AmB (1) | 0/4 | 0/4 | 0 (0) | 23.5 (0–50) | |
a
Rav, ravuconazole; AmB, amphotericin B.
b
Day 5 indicates that the median antigen levels were calculated from the 3rd day of treatment.
c
Day 9 indicates that the median antigen levels were calculated from the final antigen concentration for each rabbit.