Extended Data Fig. 7. Somatic indels and colibactin exposure.

a, Mutational spectra of somatic indels in each species. The x axis shows 83 types of insertion or deletion, coloured by type and length³⁰. b, Colibactin exposure in non-human and human colorectal crypts. Exposures to mutational signatures SBS1, SBS5, SBS18, SBS34 and SBS88, as inferred by expectation–maximization, for 180 non-human crypts in this study (top) and 445 human crypts sequenced in a previous study⁸. Asterisks indicate samples with statistically significant colibactin (SBS88) exposure, based on a LRT (Methods). BW, black-and-white; H, harbour; N, naked; RT, ring-tailed.