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. 2022 Apr 13;604(7906):517–524. doi: 10.1038/s41586-022-04618-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 12 — a, Bootstrapped regression of somatic substitution rates on the inverse of lifespan (1/lifespan), using a zero-intercept LME model (Methods). For each of 5,000 bootstrap samples (replicates), lifespan values per species were randomly chosen from a set of published maximum longevity estimates (Supplementary Table 6). The blue line indicates the median regression slope (k) across bootstrap samples, and the shaded area depicts the range of estimates of k across bootstrap samples. Black dots and error bars indicate the mean and range, respectively, of published longevity estimates for each species. The median and range of both k and the fraction of inter-species variance explained (FVE) are provided. b, Histogram of FVE values across the 5,000 bootstrap samples.