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. 2022 Apr 13;604(7906):517–524. doi: 10.1038/s41586-022-04618-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 13 — a, Zero-intercept regression of somatic substitution rates on inverse lifespan (1/lifespan), using a LME model applied to mutation rates per crypt (left) and a Bayesian hierarchical normal regression model applied to mean mutation rates per individual (Methods). For simplicity, black dots present mean mutation rates per species. Darker shaded areas indicate 95% confidence/credible intervals (CI) of the regression lines; lighter shaded areas mark a two-fold deviation from the regression lines. Point estimates and 95% CI of the regression slopes (k) and fraction of inter-species variance explained (FVE) are provided. b, Comparison of regression lines for the regression of somatic substitution rates on 1/lifespan (left; zero intercept) and log-transformed adult body mass (right; free intercept), using simple linear models (dark and light blue), phylogenetic generalized least-squares models (orange and yellow), Bayesian hierarchical normal models (green) and LME models (red) (Methods). Point estimates of the regression coefficients for each model are provided. c, Distributions of regression FVE under individual- and species-level bootstrapping. For the LME models regressing somatic mutation rates on inverse lifespan (zero intercept; left) and log-transformed mass (free intercept), the curves present distributions of FVE from 10,000 bootstrap replicates, obtained through random resampling of either individuals (blue) or species (orange) (Methods). Vertical lines indicate the FVE values obtained using the entire dataset.