Extended Data Fig. 15. Mutational signatures and exposures as inferred de novo.

a, Mutational signatures inferred de novo from the species mutational spectra shown in Fig. 2a. Signatures are shown in a human-genome-relative representation. SBSA is the de novo equivalent of COSMIC signature SBS1 (Fig. 2b). b, Exposure of each sample to each of the mutational signatures shown in a. Samples are arranged horizontally as in Fig. 1b. c, Regression of signature-specific mutation burdens on individual age for human, mouse and naked mole-rat samples. Regression was performed using mean mutation burden per individual. Shaded areas indicate 95% confidence intervals of the regression lines. BW, black-and-white; H, harbour; N, naked; RT, ring-tailed.