TABLE 2.
MICs of macrolide-lincosamide-streptogramin B antibiotics against MSB and ML strains
| Strain | MIC (μg/ml) of compounda:
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ERY | CLR | AZM | JOS | TEL | LIN | CLX | STA | STB | PEN | |
| E40 | 100 | 25 | >100 | >100 | 0.01 | 12.5 | 0.78 | 100 | 6.25 | 6.25 |
| 02J1200 | 50 | 12.5 | >100 | >100 | 0.01 | 12.5 | 0.78 | 100 | 3.12 | 0.01 |
| 117-891 | 50 | 12.5 | >100 | >100 | 0.01 | 12.5 | 0.78 | 50 | 3.12 | 0.03 |
| Bu41 | 100 | 12.5 | >100 | 100 | 0.03 | 0.78 | 0.05 | 100 | 12.5 | 6.25 |
| Sof289b | >100 | 25 | >100 | 100 | 0.1 | 0.78 | 0.1 | 100 | 12.5 | 3.12 |
| 395 | >100 | 25 | >100 | 100 | 0.1 | 1.56 | 0.1 | 100 | 12.5 | 1.56 |
| 398 | 100 | 25 | >100 | 100 | 0.03 | 0.78 | 0.05 | 100 | 12.5 | 3.12 |
| 404 | >100 | 25 | >100 | >100 | 0.2 | 1.56 | 0.1 | >100 | 25 | 6.25 |
| 407 | >100 | 25 | >100 | 100 | 0.05 | 1.56 | 0.1 | 100 | 25 | 6.25 |
| 381 | >100 | 25 | >100 | 100 | 0.05 | 0.39 | 0.05 | 100 | 25 | 6.25 |
| 386 | >100 | 50 | >100 | 100 | 0.1 | 0.39 | 0.1 | 100 | 25 | 3.12 |
| 387 | >100 | 50 | >100 | 100 | 0.1 | 0.39 | 0.1 | 100 | 25 | 1.56 |
| 442 | >100 | 25 | >100 | 100 | 0.1 | 0.78 | 0.1 | 100 | 12.5 | 6.25 |
| BM4418 | 6.25 | 12.5 | 12.5 | 6.25 | 3.12 | 0.39 | 0.05 | 50 | 25 | 0.01 |
| ATCC 49619 | 0.03 | 0.03 | 0.1 | 0.2 | 0.006 | 0.78 | 0.05 | 25 | 3.12 | 0.39 |
a
Fourteen-membered macrolides: erythromycin (ERY) and clarithromycin (CLR); 15-membered macrolide: azithromycin (AZM); 16-membered macrolide: josamycin (JOS); ketolide: telithromycin (TEL); lincosamides: lincomycin (LIN) and clindamycin (CLX); streptogramins: streptogramin A (STA) and streptogramin B (STB). PEN, penicillin G.
b
The MICs for Sof289 are representative of those for six other identical isolates (Bul23, Bul29, Bul34, Bul40, Bul91, and Bul115).