TABLE 3.
The impact of mutational frequency at position 2059 in 23S rRNA on MICsa
| Strain | A2059:G2059b | MIC (μg/ml) of compound:
|
Disk diffusion zone diam (mm) for compound:
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ERY | CLR | AZM | JOS | TYL | SPI | TEL | LIN | CLX | STA | STB | CLX | ERY | STB | ||
| R6 | 4:0 | 0.02 | 0.05 | 0.10 | 0.10 | 0.39 | 0.20 | 0.006 | 0.39 | 0.05 | 25.00 | 3.12 | 30.0 | 30.5 | 22.1 |
| ML1 | 2:2 | 3.12 | 1.56 | 400 | 1.56 | 6.25 | 3.12 | 0.006 | 6.25 | 0.10 | 50.00 | 3.12 | 22.1 | 20.6 | 19.3 |
| Z10 | 1:3 | 12.5 | 6.25 | >400 | 200 | 200 | 400 | 0.006 | 12.5 | 0.39 | 50.00 | 3.12 | 18.2 | 14.0 | 19.4 |
| Z10-Spir | 0:4 | 25 | 6.25 | >400 | 200 | 400 | 800 | 0.006 | 12.5 | 0.78 | 50.00 | 3.12 | 13.8 | 0 | 18.4 |
a
Fourteen-membered macrolides: erythromycin (ERY) and clarithromycin (CLR); 15-membered macrolide: azithromycin (AZM); 16-membered macrolides: josamycin (JOS), tylosin (TYL), and spiramycin (SPI); ketolide: telithromycin (TEL); lincosamides: lincomycin (LIN) and clindamycin (CLX); streptogramins: streptogramin A (STA) and streptogramin B (STB).
b
The ratio of the number of 23S rRNA genes harboring adenine at position 2059 to the number of genes harboring guanine there.