TABLE 4.
In vitro poly(A)-directed translation using ribosomes from isogenic strains
| Strain | IC50 (μg/ml) of compounda:
|
|||||
|---|---|---|---|---|---|---|
| ERY | AZM | JOS | TEL | CLX | STB | |
| R6 | 0.02 | 0.02 | 0.2 | 0.02 | 0.03 | 0.15 |
| ML1 | 0.08 | 0.08 | >10 | 0.04 | 0.09 | 0.3 |
| Z10 | 0.9 | 1.2 | >10 | 0.02 | 0.3 | 0.3 |
| Z10-Spir | 0.5 | 0.8 | >10 | 0.04 | 0.6 | 0.6 |
| CP1000 | 0.07 | 0.01 | 0.003 | 0.005 | 0.03 | 0.1 |
| BM4440 | 10 | 7 | 8 | 0.4 | 0.05 | >10 |
| R6 | 0.01 | 0.01 | 0.2 | 0.08 | 0.01 | 0.3 |
| R6 MSB | >10 | >10 | >10 | 0.15 | 0.03 | >10 |
a
Fourteen-membered macrolide: erythromycin (ERY); 15-membered macrolide: azithromycin (AZM); 16-membered macrolide: josamycin (JOS); ketolide: telithromycin (TEL); lincosamide: clindamycin (CLX); streptogramin: streptogramin B (STB).