TABLE 5.
MICs of macrolide-lincosamide-streptogramin B antibiotics against MSB strains and transformants
| Strain | MIC (μg/ml) of compounda:
|
Mutation | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ERY | CLR | AZM | JOS | TEL | CLX | STB | PEN | ||
| BM4419 | 0.05 | 0.03 | 0.10 | 0.20 | 0.006 | 0.05 | 1.56 | 0.03 | None |
| BM4418 | 6.25 | 12.5 | 12.5 | 6.25 | 3.12 | 0.05 | 25 | 0.03 | 63KPWRQKGTGREKGTGRAR80 |
| CP1000 | 0.03 | 0.01 | 0.05 | 0.05 | 0.003 | 0.03 | 1.56 | 0.01 | None |
| BM4440 | 3.12 | 3.12 | 3.12 | 3.12 | 1.56 | 0.03 | 25 | 0.01 | 63KPWRQKGTGREKGTGRAR80 |
| R6 | 0.02 | 0.05 | 0.10 | 0.10 | 0.003 | 0.02 | 1.56 | 0.006 | None |
| R6 MSB | 50 | >100 | 6.25 | 50 | 0.024 | 0.02 | 12.5 | 0.01 | 63KPWRQKTPSRAR74 |
| Bu41 | 100 | >100 | 12.5 | 100 | 0.05 | 0.05 | 12.5 | 3.12 | 63KPWRQKTPSRAR74 |
a
Fourteen-membered macrolides: erythromycin (ERY) and clarithromycin (CLR); 15-membered macrolide: azithromycin (AZM); 16-membered macrolide: josamycin (JOS); ketolide: telithromycin (TEL); lincosamide: clindamycin (CLX); streptogramin: streptogramin B (STB). PEN, penicillin G.