Table 2.
The importance and normalised importance of the 50 most relevant imaging variables in predicting group membership
| Rank | Imaging metric | Importance | Normalised importance (%) |
|---|---|---|---|
| 1. | MD Corticospinal Tract Rt | 0.014 | 100.0 |
| 2. | FA Corticospinal Tract Rt | 0.013 | 91.9 |
| 3. | FA Corticospinal Tract Lt | 0.011 | 80.8 |
| 4. | RD Sup Cerebellar Ped Lt | 0.010 | 75.6 |
| 5. | FA Average Cerebellar Rt | 0.010 | 73.3 |
| 6. | RD Inf. Longitudinal_Fasciculus Lt | 0.010 | 72.9 |
| 7. | FA Medial Lemniscus Lt | 0.010 | 72.3 |
| 8. | RD Uncinate Fasciculus Rt | 0.010 | 72.1 |
| 9. | FA Average Cerebellar Lt | 0.009 | 67.1 |
| 10. | AD Cingulum Lt | 0.009 | 64.2 |
| 11. | FA Forceps Major | 0.009 | 64.1 |
| 12. | MD Sup. Longitudinal Fasciculus Rt | 0.008 | 61.4 |
| 13. | AD Sup. Longitudinal Fasciculus Rt | 0.008 | 60.7 |
| 14. | MD Inf. Longitudinal Fasciculus Lt | 0.008 | 60.4 |
| 15 | RD Anterior Thalamic Radiation Lt | 0.008 | 59.3 |
| 16. | RD Medial Lemniscus Rt | 0.008 | 57.6 |
| 17. | MD Forceps Minor | 0.008 | 57.5 |
| 18. | RD Corticospinal Tract Lt | 0.008 | 56.6 |
| 19. | Lt lateraloccipital thickness | 0.008 | 56.6 |
| 20. | MD Corticospinal Tract Lt | 0.008 | 55.9 |
| 21. | RD Medial Lemniscus Lt | 0.008 | 55.6 |
| 22. | AD External Capsule Rt | 0.008 | 54.6 |
| 23. | FA Uncinate Fasciculus Rt | 0.007 | 54.2 |
| 24. | RD Sup. Cerebellar Ped Rt | 0.007 | 54.0 |
| 25. | Lt posteriorcingulate thickness | 0.007 | 53.7 |
| 26. | AD Forceps Minor | 0.007 | 53.6 |
| 27. | RD Anterior Thalamic Radiation Rt | 0.007 | 53.5 |
| 28. | FA Inf. Cerebellar Peduncle Rt | 0.007 | 53.1 |
| 29. | FA Inf. Longitudinal Fasciculus Rt | 0.007 | 52.4 |
| 30. | Lt precentral thickness | 0.007 | 51.1 |
| 31. | RD Average Cerebellar Lt | 0.007 | 51.0 |
| 32. | RD Inf. Cerebellar Peduncle Lt | 0.007 | 51.0 |
| 33. | MD Middle Cerebellar Peduncle | 0.007 | 50.7 |
| 34. | RD Inf. Cerebellar Peduncle Rt | 0.007 | 50.1 |
| 35. | FA Inf. Cerebellar Peduncle Lt | 0.007 | 49.9 |
| 36. | MD Post. Thalamic Radiation Rt | 0.007 | 49.8 |
| 37. | MD Inf. Fronto-Occipital Fasciculus Rt | 0.007 | 49.7 |
| 38. | FA Inf. Longitudinal Fasciculus Lt | 0.007 | 49.3 |
| 39. | FA Sup. Cerebellar Peduncle Lt | 0.007 | 48.8 |
| 40. | MD Medial Lemniscus Lt | 0.007 | 48.3 |
| 41. | Lt Caudal middle frontal thickness | 0.007 | 48.2 |
| 42. | AD Medial Lemniscus Rt | 0.007 | 47.4 |
| 43. | Left-Amygdala Volume % | 0.007 | 47.1 |
| 44. | RD Middle Cerebellar Peduncle | 0.007 | 47.0 |
| 45. | MD Anterior Thalamic Radiation Rt | 0.006 | 46.8 |
| 46. | FA Uncinate Fasciculus Lt | 0.006 | 45.7 |
| 47. | FA Medial Lemniscus Rt | 0.006 | 45.4 |
| 48. | RD Forceps Major | 0.006 | 45.3 |
| 49. | RD Forceps Minor | 0.006 | 45.0 |
| 50. | MD External Capsule Rt | 0.006 | 45.0 |
AD axial diffusivity, ALS amyotrophic lateral sclerosis, DC disease control, FA fractional anisotropy, HC healthy control, Lt left, MD mean diffusivity, RD radial diffusivity, Rt right