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. 2022 Apr 21;8:36. doi: 10.1038/s41421-022-00401-6

Fig. 5. Prophylactic and therapeutic effect of G9 against SARS-CoV-2 infection of lung, brain, and associated disease in hACE2-transgenic mice.

Fig. 5

a Experimental scheme of the animal model. b Bodyweight changes in SARS-CoV-2-infected HFH4-hACE2-transgenic mice in the prevention group (P), treatment group (T), and PBS group of GW01 and G9. The percentage of weight change was calculated on day 5 for all animals. The symbol “+” signifies that the mice died. c, d Viral load as assessed by S gene RNA RT–PCR from lung tissue of the GW01 and G9 groups (c) or brain tissue from the G9 groups (d) on day 5 post infection. e Pathological changes in HFH4-hACE2-transgenic mouse lung on day 5 after SARS-CoV-2 infection. Mouse lung tissue was stained with H&E to observe pathological changes. Scale bars, 200 μm. f Viral antigen was detected by anti-SARS-CoV-2 N protein polyclonal antibody (red) in lung bronchi and alveoli collected 5 DPI. Images were collected using a Pannoramic MIDI system (3DHISTECH, Budapest). Scale bars, 100 μm.