FIG. 1.
Genomic organization of retroviral vector pG1Na carrying the HBV genome 1.1 times the length of the fully functional HBV genome. A portion of HBV genome construction was adopted from a previous study (10). Solid arrows, HBV open reading frames; dashed arrows, mRNA transcripts driven by HBV promoters. Abbreviations: LTR, long terminal repeat sequence; NeoR, neomycin resistance gene; P, HBV DNA polymerase; C, HBV core antigen; S, HBsAg; X, HBV X protein; DR, direct repeat sequence; ENI and ENII, HBV enhancers I and II, respectively; Cp Sp, and Xp, HBV core gene, surface antigen gene, and X gene promoters, respectively.