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. 2022 Apr 20;5:383. doi: 10.1038/s42003-022-03324-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, c, e Cumulative locomotor activity recorded in a circular corridor during the 2 h-test for control (ERα^fl/fl) and mutant (ERα^NesCre) females (a, n = 11–13 per genotype), control (ERα^fl/fl) and mutant (ERα^NesCre) males (c, n = 10–11 per genotype), or control (AR::ERα^fl/fl) and mutant (AR::ERα^NesCre) males (e, n = 7–11 per genotype). b, d, f Anxiety-related behavior measured in the elevated O-maze for control (ERα^fl/fl) and mutant (ERα^NesCre) females (b, n = 11–13 per genotype), control (ERα^fl/fl), and mutant (ERα^NesCre) males (d, n = 10-11 per genotype), or control (AR::ERα^fl/fl) and mutant (AR::ERα^NesCre) males (f, n = 7-11 per genotype). The latency to enter the open arm (left) and the time spent in the open arm (right) were analyzed. g, h Percentage of males from the ER^NesCre (g) or AR::ERα^NesCre (h) mouse lines displaying aggressive behavior towards non-aggressive males in the resident-intruder test across two or three tests. *p < 0.05, **p < 0.01 versus the control group. Data are shown as means ± S.E.M. with individual values (panels a–f) or as percentage (panels g, h).