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. 2022 Apr 20;8:214. doi: 10.1038/s41420-022-01014-4

Fig. 2. Inhibition of ENO1 reversed the effect of lactate on the growth of LM3 organoids.

Fig. 2

A Bright-field images of LM3 organoids treated with 20 mM lactate or AP-III-a4. Scale bars in ×100 row refer to 200 μm and scale bars in ×200 row refer to 100 μm. B Viability of LM3 organoids treated with 20 mM lactate or AP-III-a4. C Immunoblot showing bands corresponding to HIF1α, PI3K, p-PI3K, AKT, p-AKT, and β-actin. D Quantification of the above proteins, p-PI3K/PI3K ratio, and p-AKT/AKT ratio in the indicated groups. *P < 0.05.