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. 2022 Apr 20;8:214. doi: 10.1038/s41420-022-01014-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The number of SNPs in the different regions of the genome in original tissues and PDOs without or with 20 mM lactate treatment. The regions are shown in the legends. B The proportion of the six types of base substitutions and InDels in original tissues and PDOs without or with 20 mM lactate treatment. C The similarity of genetic profiles between original tissues and PDOs without or with 20 mM lactate treatment. D Representative genetic variants in original tissues and PDOs without or with 20 mM lactate treatment. The types of variants are shown in the legends.