Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 20;5:384. doi: 10.1038/s42003-022-03330-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a The inhibitory gain of each node in the balanced DMF model is modulated by the regional density of GABA-A receptors, estimated from PET. b Box-plots show the model fit for n = 100 simulations, quantified as the KS-distance (lower is better) to the functional connectivity dynamics (FCD) derived from the propofol (anaesthetised) condition, using a value of gain for inhibitory scaling s_I derived from calibrating the model with respect to either the awake (blue) or propofol (grey on shaded background) conditions. Middle line: median; box limits, upper and lower quartiles; whiskers, 1.5x inter-quartile range; “+” symbol indicates outliers; ***p < 0.001 from t-test. Source data are provided in Supplementary Data 1. We replicated this result using an alternative version of the KS-distance, which in addition to the distribution of FCD values also takes into account the temporal lag between them (Supplementary Fig. 2).