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. 2022 Apr 20;5:384. doi: 10.1038/s42003-022-03330-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The original healthy connectome of the model is replaced with the group-average connectome obtained from diffusion MRI of n = 21 DOC patients, and the resulting model is used to generate n = 100 simulations. b–e Box-plots show the difference in model fit (KS-distance) between the two conditions (fit to DOC patients’ data minus fit to healthy controls’ data, over n = 100 simulations), for the initial model calibrated based on the healthy connectome (b), and after replacing the model’s initial connectome with either the DOC patients’ empirical consensus connectome (c), or after rewiring the initial connectome into a random network (d), or into a regular (lattice) network (e). Middle line: median; box limits, upper and lower quartiles; whiskers, 1.5x inter-quartile range; “+” symbol indicates outliers; ***p < 0.001; n.s. Not significant (p > 0.05) from t-test. Source data are provided in Supplementary Data 2. We replicated this result using an alternative version of the KS-distance, which in addition to the distribution of FCD values also takes into account the temporal lag between them (Supplementary Fig. 3).