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. 2022 Apr 20;5:384. doi: 10.1038/s42003-022-03330-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Box-plots show the KS-distance (lower is better) to the empirical brain activity of DOC patients, for n = 100 simulations of a model that (a) is informed by empirical GABA-A regional density, using the value of gain for inhibitory scaling s_I derived from calibrating the model with respect to healthy controls’ empirical brain activity (blue); (b) is informed by empirical GABA-A regional density, using the value of gain for inhibitory scaling s_I that provides the best fit to the DOC patients’ empirical brain activity (red); (c) same as (b), but the regional receptor densities are randomly reshuffled across the cortex; (d) same as (b), but the receptor densities are all set to a uniform value (the mean of the empirical distribution). Middle line: median; box limits, upper and lower quartiles; whiskers, 1.5x inter-quartile range; “+” symbol indicates outliers; ***p < 0.001. n.s. Not significant (p > 0.05) from t-test. Source data are provided in Supplementary Data 3.