Table 1.

Physicochemical characteristics and in vitro activities of pantothenamides.

Compound	Chemical structure	Asexual blood stage IC50 range (N)	Gametocyte IC50 range (N)	Human hepatocyte CLint (µl/min/106 cells)	Molecular Weight (g/mol)	Crystalline	Melting temperature (°C)
(1) MMV689258		5* nM	12* nM	0.8	354.4164	Yes	48.1
(2) MMV693183		2.1-2.8 (4) nM	17.8-38.8 (3) nM	0.4	362.3441	Yes	91.6
(3) MMV884962		7.4-12 (2) nM	2.2-5.9 (2) nM	0.3	333.3822	No	N/A
(4) MMV1542001		1.9-2.4 (2) nM	2.0-9.9 (2) nM	0.5	326.3632	No	N/A
(5) MMV693182		6.2-7.5 (2) nM	21.4-32.9 (2) nM	0.2	351.3727	Yes	107.9 (1-1) 112.7 (1-2)
(6) MMV976394		6.2-24.9 (2) nM	> 1 µM (2)	0.2	337.3461	No	N/A

IC₅₀ values were determined using a nonlinear regression with four-parameter model and the least-squares method to find the best fit. The IC₅₀ range is shown from two to four independent experiments (N) with technical duplicates measured in a 72-h asexual growth assay or sexual viability assay. Crystallization of MMV693182 resulted in two polymorphs. *Data retrieved from Schalkwijk et al.¹⁵. N/A: not applicable. Source data are provided as Source Data file.