Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 20;12:6511. doi: 10.1038/s41598-022-10411-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The number of FKBP5rs3800373 risk alleles moderates the relationship between the right hippocampus and CMP severity. Shown is the relationship between right hippocampal brain volume and chronic multisite musculoskeletal pain (CMP) severity in individuals from the UKBB study cohort (n = 36,822). Right hippocampal brain volume was adjusted for head size and standardized (mean = 0, SD = 1), see “Methods”. Individuals with two copies of the FKBP5rs3800373 risk allele (n = 3005) are represented by the blue line, individuals with one copy of the FKBP5rs3800373 risk allele (n = 15,327) are represented by the red line, and individuals with no risk alleles are represented by the green line (n = 18,490). As shown in Supplementary Table 4, relationships represented by the blue and red lines were statistically significant (p < 0.05).