Table 2.

Linear regression analyses assessing the interaction between FKBP5 genetic risk, using the tagging allele rs3800373, and left and right hippocampal volumes on chronic multisite musculoskeletal pain in the UK Biobank (n = 36,822).

	Left hippocampus			Right hippocampus
	β	S.E.	p value		β	S.E.	p value
Intercept	−0.302	0.047	< 0.001		−0.299	0.047	< 0.001
FKBP5rs3800373	−0.003	0.007	0.692		−0.003	0.007	0.694
Hippocampal volume	0.003	0.006	0.638		0.004	0.006	0.476
Age	0.001	0.0006	0.057		0.001	0.0006	0.065
Sex	−0.116	0.009	< 0.001		−0.117	0.009	< 0.001
BMI	0.029	0.001	< 0.001		0.029	0.001	< 0.001
Genotyping array	0.011	0.014	0.461		0.011	0.014	0.444
Imaging center (Reading)	−0.020	0.013	0.137		−0.020	0.013	0.133
Imaging center (Newcastle)	0.026	0.010	0.012		0.026	0.010	0.013
FKBP5rs3800373* Hippocampal volume	−0.015	0.007	0.023		−0.020	0.007	0.002

Chronic multisite musculoskeletal pain was defined as the number of musculoskeletal sites with pain that persisted for more than 3 months, ranging from 0 to 4. An additive genetic model was used to assess the effect of rs3800373. Genetic principal components 1–10 and ethnic background were included as covariates but omitted from the table for brevity.